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Enoyl-acyl carrier protein reductase (or ENR) (), is a key enzyme of the type II fatty acid synthesis (FAS) system. 〔Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum. / Biochem J. 2004 Aug 1;381(Pt 3):735-41. PMID 15139852〕 ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.〔Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase. / Antimicrob Agents Chemother. 2004 May;48(5):1541-7. PMID 15105103〕 At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria ''Streptococcus pneumoniae''. == See also == * Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific) * Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) * Cis-2-enoyl-CoA reductase (NADPH) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Enoyl-acyl carrier protein reductase」の詳細全文を読む スポンサード リンク
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